2. Cirrhosis
Liver disease can cause the enlargement of the spleen, known as splenomegaly, and one of the most common causes is cirrhosis. Other symptoms of cirrhosis include an enlarged liver, known as hepatomegaly, jaundice, and edema in the lower extremities.
It is important that patients with cirrhosis receive prompt treatment to reduce the risk of developing hepatic encephalopathy. Common treatments for cirrhosis include medications to reduce inflammation, lifestyle changes, and potentially a liver transplant.