Enlarged Spleen (Splenomegaly) Symptoms and Causes

3. Leukemia

People suffering from blood cancers can have an enlarged spleen because the faulty blood cells become confined and processed by the organ.

The spleen increases in size due to the surplus amount of work it must do. Other symptoms that those with leukemia may experience include tiredness, general discomfort, rapid heart rate, lack of appetite, weight loss, pain in the joints, and soreness in their bones.