Enlarged Spleen (Splenomegaly) Symptoms and Causes

4. Pancreatic cancer

In certain cancer cases, the splenic vein is compressed, leading to the blood going backward to the spleen instead of to the heart. This can cause an enlargement of the spleen known as congestive splenomegaly. Patients with this condition can display anorexia, back pain, weight loss, gastrointestinal bleeding, fatigue, and weakness.