Enlarged Spleen (Splenomegaly) Symptoms and Causes

5. Polycythemia vera

Polycythemia vera is linked to considerable enlargement of the spleen, causing additional issues such as a feeling of heaviness in the abdomen, quickly becoming full after eating, and abdominal discomfort. Other signs of this condition include exhaustion, tiredness, shortness of breath, vertigo, dizziness, and raised blood pressure.